Original article



Download 62.87 Kb.
Page1/9
Date06.01.2018
Size62.87 Kb.
  1   2   3   4   5   6   7   8   9

ORIGINAL ARTICLE


ANTI-CONVULSANT ACTIVITY OF GANAXOLONE ALONE AND IN COMPARISON WITH STANDARD ANTI-EPILEPTIC DRUGS IN RODENT MODELS

Mr. S.K. Subhani Basha, Dr .B. L. Kudagi, Dr. R. Pravin Kumar





  1. Tutor, Department of Pharmacology, Narayana Medical College, Nellore.

  2. Professor & H.O.D., Department of Pharmacology, Narayana Medical College, Nellore.

  3. PG Student, Department of Pharmacology, Narayana Medical College, Nellore.


CORRESPONDING AUTHOR:

Dr .B. L. Kudagi,

Professor & H.O.D.,

Department of Pharmacology,

Narayana Medical College,

Nellore.


Email ID- blkudagi@rediffmail.com
ABSTRACT:

BACKGROUND: Presently, treatment of epilepsy with standard anti-epileptic drugs is associated with a number of shortcomings inviting us to study newer agents that would overcome these problems or search for the drugs or substances, which would enhance the efficacy or reduce the dose or toxicity of these standard anti-epileptic drugs. Ganaxolone (GNX) (3α-hydroxy-3β-methyl-5α-pregnan-20-one), a synthetic analog of the endogenous neurosteroid allopregnanolone and a positive allosteric modulator of GABAA receptors, may represent a new treatment approach for epilepsy. AIM: To evaluate the effect of Ganaxolone on maximal electroshock (MES) induced and Pentylenetetrazol (PTZ) induced convulsions and also their effect in combination with conventional antiepileptic drugs (CAEDs). MATERIAL AND METHODS: Wister strain albino rats weighing 200-250 gm were used. Effects of Ganaxolone (5 &10 mg/kg) alone and in combination with standard drugs were studied in MES and PTZ induced seizure models. Abolition of tonic hind limb extension was an index of anticonvulsant activity in MES, while for PTZ seizures; failure to observe clonus for 5sec duration for 30min was the index. Following that, percentage inhibition was calculated. STATISTICS: ANOVA followed by Newman-Keuls Multiple Comparison Test was used for analysis of data between the groups. RESULTS: In MES seizures, significant anti-epileptic activity was observed with 10mg of Ganaxolone compared to control group but has less activity when compared to that of Phenobarbitone. In PTZ induced convulsions, the anti-epileptic effect of Sodium Valproate was higher than Ganaxolone, but both were statistically significant as compared to control. In PTZ-induced seizures, augmented effects were obtained when Ganaxolone was combined with sodium valproate i.e. 55%. CONCLUSIONS: The results provide a lead for potential benefit of adding Ganaxolone to Sodium Valproate in the treatment of epilepsy, which needs to be explored further.




Share with your friends:
  1   2   3   4   5   6   7   8   9


The database is protected by copyright ©psyessay.org 2017
send message

    Main page
mental health
health sciences
gandhi university
Rajiv gandhi
Chapter introduction
multiple choice
research methods
south africa
language acquisition
Relationship between
qualitative research
literature review
Curriculum vitae
early childhood
relationship between
Masaryk university
nervous system
Course title
young people
Multiple choice
bangalore karnataka
state university
Original article
academic performance
essay plans
social psychology
psychology chapter
Front matter
United states
Research proposal
sciences bangalore
Mental health
compassion publications
workplace bullying
publications sorted
comparative study
chapter outline
mental illness
Course outline
decision making
sciences karnataka
working memory
Literature review
clinical psychology
college students
systematic review
problem solving
research proposal
human rights
Learning objectives
karnataka proforma